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Chronic renal failure is a slowly worsening loss of the ability of the kidneys to remove wastes, concentrate urine, and conserve electrolytes.
Chronic kidney disease (CKD), also known as chronic renal disease, is a progressive loss of renal function over a period of months or years. The symptoms of worsening kidney function are unspecific, and might include feeling generally unwell and experiencing a reduced appetite. Often, chronic kidney disease is diagnosed as a result of screening of people known to be at risk of kidney problems, such as those with high blood pressure or diabetes and those with a blood relative with chronic kidney disease. Chronic kidney disease may also be identified when it leads to one of its recognized complications, such as cardiovascular disease, anemia or pericarditis.
Chronic kidney disease is identified by a blood test for creatinine. Higher levels of creatinine indicate a falling glomerular filtration rate (rate at which the kidneys filter blood) and as a result a decreased capability of the kidneys to excrete waste products. Creatinine levels may be normal in the early stages of CKD, and the condition is discovered if urinalysis (testing of a urine sample) shows that the kidney is allowing the loss of protein or red blood cells into the urine. To fully investigate the underlying cause of kidney damage, various forms of medical imaging, blood tests and often renal biopsy (removing a small sample of kidney tissue) are employed to find out if there is a reversible cause for the kidney malfunction.
Recent professional guidelines classify the severity of chronic kidney disease in five stages, with stage 1 being the mildest and usually causing few symptoms and stage 5 being a severe illness with poor life expectancy if untreated. Stage 5 CKD is also called established chronic kidney disease and is synonymous with the now outdated terms end-stage renal disease (ESRD), chronic kidney failure (CKF) or chronic renal failure (CRF).
Causes of Chronic renal failure:
The most common causes of CKD are diabetic nephropathy, hypertension, and glomerulonephritis. Together, these cause approximately 75% of all adult cases. Certain geographic areas have a high incidence of HIV nephropathy.
Historically, kidney disease has been classified according to the part of the renal anatomy that is involved, as:
• Vascular, includes large vessel disease such as bilateral renal artery stenosis and small vessel disease such as ischemic nephropathy, hemolytic-uremic syndrome and vasculitis
• Glomerular, comprising a diverse group and subclassified into
1. Primary Glomerular disease such as focal segmental glomerulosclerosis and IgA nephritis
2. Secondary Glomerular disease such as diabetic nephropathy and lupus nephritis
• Tubulointerstitial including polycystic kidney disease, drug and toxin-induced chronic tubulointerstitial nephritis and reflux nephropathy.
• Obstructive such as with bilateral kidney stones and diseases of the prostate.
• Gout.
Symptoms of Chronic renal failure
Initial symptoms may include the following:
• Fatigue
• Frequent hiccups
• General ill feeling
• Generalized itching (pruritus)
• Headache
• Nausea, vomiting
• Unintentional weight loss.
• Anorexia.
• Polyuria.
• Nocturia.
• Swelling of face.
Later symptoms may include the following:
• Blood in the vomit or in stools
• Decreased alertness, including drowsiness,confusion, delirium, orcoma
• Decreased sensation in the hands, feet, or other areas
• Easy bruising or bleeding
• Increased or decreased urine output
• Muscle twitching or cramps
• Seizures
• White crystals in and on the skin (uremic frost).
• Hallucinations.
• Fits.
• Stupor.
Additional symptoms that may be associated with this disease:
• Abnormally dark or light skin
• Agitation
• Breath odor
• Excessive nighttime urination
• Excessive thirst
• High blood pressure
• Loss of appetite
• Nail abnormalities
• Paleness
• diarrhea.
• Oliguria.
• Dyspnoea.
• Pain in chest.
• Hiccough.
• Cramps.
• Bone pains.
• Bruises.
• Epistaxis.
Complications
• Anemia
• Cardiac tamponade
• Changes in blood sugar metabolism
• Congestive heart failure
• Decreased functioning of white blood cells
• Decreased immune response
• Decreased libido, impotence
• Dementia
• Electrolyte abnormalities including hyperkalemia
• Encephalopathy
• End-stage renal disease
• Fractures
• Hemorrhage
• High blood pressure
• Increased infections
• Joint disorders
• Liver inflammation (hepatitis B or hepatitis C)
• Liver failure
• Loss of blood from the gastrointestinal tract
• Menstrual irregularities,mscarriage, infertility
• Nerve damage
• Pericarditis
• Peripheral neuropathy
• Platelet dysfunction
• Ulcers
• Seizures
• Skin dryness, itching /scratching with resultant skin infection
• Weakening of the bones
• Uraemic coma.
• Cardiac arrhythmia.
Chronic kidney disease (CKD), also known as chronic renal disease, is a progressive loss of renal function over a period of months or years. The symptoms of worsening kidney function are unspecific, and might include feeling generally unwell and experiencing a reduced appetite. Often, chronic kidney disease is diagnosed as a result of screening of people known to be at risk of kidney problems, such as those with high blood pressure or diabetes and those with a blood relative with chronic kidney disease. Chronic kidney disease may also be identified when it leads to one of its recognized complications, such as cardiovascular disease, anemia or pericarditis.
Chronic kidney disease is identified by a blood test for creatinine. Higher levels of creatinine indicate a falling glomerular filtration rate (rate at which the kidneys filter blood) and as a result a decreased capability of the kidneys to excrete waste products. Creatinine levels may be normal in the early stages of CKD, and the condition is discovered if urinalysis (testing of a urine sample) shows that the kidney is allowing the loss of protein or red blood cells into the urine. To fully investigate the underlying cause of kidney damage, various forms of medical imaging, blood tests and often renal biopsy (removing a small sample of kidney tissue) are employed to find out if there is a reversible cause for the kidney malfunction.
Recent professional guidelines classify the severity of chronic kidney disease in five stages, with stage 1 being the mildest and usually causing few symptoms and stage 5 being a severe illness with poor life expectancy if untreated. Stage 5 CKD is also called established chronic kidney disease and is synonymous with the now outdated terms end-stage renal disease (ESRD), chronic kidney failure (CKF) or chronic renal failure (CRF).
Causes of Chronic renal failure:
The most common causes of CKD are diabetic nephropathy, hypertension, and glomerulonephritis. Together, these cause approximately 75% of all adult cases. Certain geographic areas have a high incidence of HIV nephropathy.
Historically, kidney disease has been classified according to the part of the renal anatomy that is involved, as:
• Vascular, includes large vessel disease such as bilateral renal artery stenosis and small vessel disease such as ischemic nephropathy, hemolytic-uremic syndrome and vasculitis
• Glomerular, comprising a diverse group and subclassified into
1. Primary Glomerular disease such as focal segmental glomerulosclerosis and IgA nephritis
2. Secondary Glomerular disease such as diabetic nephropathy and lupus nephritis
• Tubulointerstitial including polycystic kidney disease, drug and toxin-induced chronic tubulointerstitial nephritis and reflux nephropathy.
• Obstructive such as with bilateral kidney stones and diseases of the prostate.
• Gout.
Symptoms of Chronic renal failure
Initial symptoms may include the following:
• Fatigue
• Frequent hiccups
• General ill feeling
• Generalized itching (pruritus)
• Headache
• Nausea, vomiting
• Unintentional weight loss.
• Anorexia.
• Polyuria.
• Nocturia.
• Swelling of face.
Later symptoms may include the following:
• Blood in the vomit or in stools
• Decreased alertness, including drowsiness,confusion, delirium, orcoma
• Decreased sensation in the hands, feet, or other areas
• Easy bruising or bleeding
• Increased or decreased urine output
• Muscle twitching or cramps
• Seizures
• White crystals in and on the skin (uremic frost).
• Hallucinations.
• Fits.
• Stupor.
Additional symptoms that may be associated with this disease:
• Abnormally dark or light skin
• Agitation
• Breath odor
• Excessive nighttime urination
• Excessive thirst
• High blood pressure
• Loss of appetite
• Nail abnormalities
• Paleness
• diarrhea.
• Oliguria.
• Dyspnoea.
• Pain in chest.
• Hiccough.
• Cramps.
• Bone pains.
• Bruises.
• Epistaxis.
Complications
• Anemia
• Cardiac tamponade
• Changes in blood sugar metabolism
• Congestive heart failure
• Decreased functioning of white blood cells
• Decreased immune response
• Decreased libido, impotence
• Dementia
• Electrolyte abnormalities including hyperkalemia
• Encephalopathy
• End-stage renal disease
• Fractures
• Hemorrhage
• High blood pressure
• Increased infections
• Joint disorders
• Liver inflammation (hepatitis B or hepatitis C)
• Liver failure
• Loss of blood from the gastrointestinal tract
• Menstrual irregularities,mscarriage, infertility
• Nerve damage
• Pericarditis
• Peripheral neuropathy
• Platelet dysfunction
• Ulcers
• Seizures
• Skin dryness, itching /scratching with resultant skin infection
• Weakening of the bones
• Uraemic coma.
• Cardiac arrhythmia.
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